Disorder characterized by oedema of the subcutaneous tissue, particularly of the lips, eyelids and genitalia, though any part of the body may be involved. The tongue and larynx may also be affected. Quincke's oedema may occur in urticaria, anaphylaxis, and serum sickness. Etiologic factors include medications (e.g. penicillin, aspirin, phenytoin), infections and food related products for Quincke's oedema associated with urticaria. Venoms, food and medication can induce anaphylaxis in sensitized individuals. Hereditary angio-oedema is an autosomal-dominant disorder characterized by recurrent episodes of oedema of the subcutaneous tissue without urticaria. Onset is usually in early childhood but may be delayed even into late adult life. Two genetic variants have been described. Either serum levels of C1-esterase inhibitor are either extremely low, or the inhibitor is apparently non-functional.
Quincke's Oedema, Angioneurotic Oedema
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