Characteristic clinical entity which may precede the development of one of a variety of ichthyoses or occur as an isolated and self-limiting condition. Lamellar ichthyosis and non-bullous ichthyosiform erythroderma are most commonly preceded by the collodion baby phenotype. An initial collodion baby phase has also been reported in other disorders, e.g. in trichothiodystropy. The infants are born covered with a yellow-brown, glistening, film-like membrane resembling collodion, often resulting in ectropion and eversion of the lips. Within hours this membrane dries and cracks, and it peels off within 1 or 2 days, but may reform several times. The collodion baby is at risk because of increased insensible water loss through the skin, which may result in acute renal failure and/ or permanent brain damage if fluid replacement is neglected. Pulmonary infections and septicaemia may also occur.
Collodion Baby, Lamellar Desquamation of the New-born, Lamellar Exfoliation of the New-born
Collodion baby, Collodion baby syndrome, Harlequin fetus