Systemic disease characterized by the association of immunological abnormalities with pathological changes affecting a number of organ systems. The main clinical features include fever, rashes and arthritis, as well as renal, pulmonary, cardiac and neurological involvement, the renal changes being very important in assessing the prognosis. Skin involvement may include cutaneous erythema, particularly on light-exposed areas, rashes, a butterfly blush or discrete maculopapular eruptions with fine scaling on the cheeks or elsewhere, centrifugal annular erythema or discoid lesions. Bullous lesions, livedo reticularis, urticaria vasculitis and scarring alopecia may also occur.
Systemic Lupus Erythematosus, Lupus Erythematosus Visceralis